I wanted to suggest Poisons, again. Yes again though it has been a few years and hasn't been implemented (from what I can see)... Anyway I was researching (reference purposes) and this is what I came up with. This was taken from
http://www.gateway-africa.com/howdidthey/poisonforarrows.html and edited for forum proposes.
-Plant poisons
There are hundreds of plants AND COMBINATIONS of plants used to produce effective poisons. Three of the most popular or poisonous are from Strophanthus, Acokanthera, and Euphorbia.
In explaining the methods of extracting poison from these three plants will cover most but not all extraction methods. Every hunter or clan have its own way, ritual, additives and method of making poison.
Strophantus.(Flower)
The seeds are collected, crushed and mix with water or other additives to form a paste, the paste is then left in strong sunlight for several hours before use.
Acokanthera.(Bush)
All parts of the plant can be used. Stems, roots, or even leaves, but wood chips are preferred, are put in a large container, filled with water and boiled for up to 12 hours. Additional water is added in case the water evaporates before this time period is attained. Once all the water has evaporated, a thick sticky black substance is left in the container.
The plant parts are discarded. This substance is then cut into pieces, put into containers or wrapped and stored away from people where it can later be mixed with water or tree gum to form a thick paste.
Euphorbia.(cactus)
The trunks are cut and the white latex collected which was then smeared on the arrows, sometimes the latex was collected slowly ”cooked” and then used.
Adenium boehmianum (flowering fern-like little tree)
Thick branches and roots were heated over a fire until a sticky sap exudes which was collected and cooled on a piece of wood.
The efficiency of these poisons are pretty fatal but for game purposes they shouldn't be. Degenerates your health but NEVER kills you. Once your poisoned past a certain x% damage, tiredness, thirst, and hunger you become immune to that particular poison and can then regenerate without hindrance. The most fatal shouldn't do more than, say 75% total. Meaning that over time it would leave you with a total of 25% health.
Maybe even best if plants needed to be combined.
-Animal Poisons
There are also bugs and other animals that poison can be made from.
Drying larvae/pupae in the sun, grinding them into powder and then mixing the powder with plant juices.
Making a mixture of beetle larvae/pupae with plant juice and water and/or tree gum. The plant juice/gum acts as an adhesive and in some cases as a second toxin.
Snakes venom can be acquired by a live snake's head being held firmly and then applying pressure to the glands above their fangs with a tool into a container.
Considering the simplicity of the animal poisons I suggest a "Capture" project with a chance of fail which could tie into helping with domestication. Also maybe a chance of poisoning yourself in the process of capture or fabrication of poison.
From this, we can see already that a lot of tools are going to be needed which won't make it easy. After that there are the projects involved. Ingre. Amount VS Yield can be set so there's more work versus yield to make it a valuable item considering it will be valuable the same. It would simply make it more difficult to obtain as well.
Poisons are useful for many things and one is hunting. Even if the food poisons you, people living in that area will become immune and thus unaffected over time. Poisons may also be used for plots or coos, increasing damage, tiredness, thirst, and hunger to a leader or civilization through frontal attacks, poisoning cooking projects, and attacking livestock for that limited window of time.
Please give this some serious consideration. Thank you for your time.